Of Pseudomonas, porins, pumps and carbapenems
نویسندگان
چکیده
منابع مشابه
Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii.
Acinetobacter baumannii is an opportunistic pathogen, causing infections mainly in patients in intensive care units where the extensive use of antimicrobial agents can select for the emergence of multiresistant strains. In fact, since strains resistant to all antimicrobial agents have been reported, A. baumannii is considered the paradigm of multiresistant bacteria. Both acquired and intrinsic ...
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antimicrobial activity of carbapenems, the postantibiotic effect (PAE) is a prominent feature. Carbapenems have been shown to produce PAEsnot only against Grampositive bacteria but also against Gram-negative bacteria by several investigators1 ~ 5). The aim of the present study was to simultaneously compare the PAE of newer carbapenems (such as meropenemand biapenem) with that of imipenemagainst...
متن کاملRoles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae.
Two clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of beta-lactamase in resistance was investigated by eliminating the original ESBL and introducing plasmids encoding various ESBLs and AmpC beta...
متن کاملFunction of pseudomonas porins in uptake and efflux.
Porins are proteins that form water-filled channels across the outer membranes of Gram-negative bacteria and thus make this membrane semipermeable. There are four types of porins: general/nonspecific porins, substrate-specific porins, gated porins, and efflux porins (also called channel-tunnels). The recent publication of the genomic sequence of Pseudomonas aeruginosa PAO1 has dramatically incr...
متن کاملIdentification and characterization of porins in Pseudomonas aeruginosa.
Earlier studies have shown that the major porin species in Pseudomonas aeruginosa outer membrane is protein F (OprF), which produces channels wider than those produced by Escherichia coli porins. In contrast, Yoshihara and Nakae ((1989) J. Biol. Chem. 264, 6297-6301) reported that protein F has no pore-forming activity as measured by the flux of L-arabinose, and that the channels in P. aerugino...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2001
ISSN: 1460-2091
DOI: 10.1093/jac/47.3.247